We further characterized the 11 Manganese Metabolism Core Genes (MMCGs) and discovered that EIF4EBP1, RIMKLA, and BIRC5 exhibit higher expression in tumour tissues, whereas CEL, MPPED2, PCK1, CAT, PLG, PPARGC1A, PEBP1, and TFAP2A show lower expression in tumour tissues (Fig. S1A). The gene discussed is TFAP2A; the disease is neoplasm.