,6 Biallelic disease-causing variants in CRB1 (OMIM *60420) are associated with a broad spectrum of inherited retinal disease (IRD) phenotypes: (1) Leber congenital amaurosis (LCA); (2) early-onset severe retinal dystrophy; (3) rod–cone dystrophy, which can occur in conjunction with preserved para-arteriolar retinal pigment epithelium (PPRPE) and/or a Coats-like exudative vasculopathy; (4) cone–rod dystrophy; (5) macular dystrophy; (6) foveal retinoschisis; and (7) fenestrated slit maculopathy.7 Here, CRB1 is linked to Leber congenital amaurosis.