Malaria severity in pre-anemic mice was exacerbated as denoted by the increased parasitemia and markers of liver injury (serum total bile acids [TBA], alanine transaminase [ALT]), multi-organ injury (aspartate transaminase [AST]) and inflammation (lipocalin 2 [Lcn2], serum amyloid A [SAA]). The gene discussed is LCN2; the disease is parasitic infectious disease.