In patients with melena, the serum IL‐18 level was higher (p = 0.025), and in patients with intussusception serum levels of TNF‐R1 and IFN‐ɣ were significantly higher compared to patients without intussusception (p = 0.033 and p = 0.033, respectively). This evidence concerns the gene TNFRSF1A and Intussusception.