FTO and major depressive disorder: In the hippocampus, m6A methylation affects neural plasticity by modulating the miR-124-C/EBPα-FTO transcriptional axis, which regulates the expression of neural plasticity-related genes, such as Nr3c1, Creb1, Bdnf, and Ntrk2, in the learned helplessness rat model, a key paradigm for studying depression.52