Three of these six cases normalized PRL levels spontaneously at the last follow-up visit, while in the other three patients, a tumoral rest was identified and hyperprolactinemia persisted in the following visits and were medically treated (cabergoline in monotherapy in one case with isolated hyperprolactinemia, and fgSRL in monotherapy in two patients with high IGF-1 and PRL levels). This evidence concerns the gene PRL and hyperprolactinemia.