POC5 and scoliosis: In addition, a common variant (single-nucleotide variation [formerly polymorphism] rs6892146, chr5(GRCh38):g.75676165C>G NM_0010992 71.2:c.1585–1587G>C), located in intron 11 of POC5, was associated with scoliosis susceptibility in the Chinese population.8 This variant was reported to result in an increased POC5 mRNA expression.