POC5 and night blindness: A homozygous loss-of-function (LoF) variant in POC5 centriolar protein (POC5, HGNC:26658) was initially described in an individual with retinitis pigmentosa (RP).1 RP encompasses a heterogeneous group of inherited retinal disorders characterized by progressive degeneration of photoreceptor cells, leading to night blindness, peripheral visual field loss, and eventual blindness.