Via validated axes like hsa_circ_0084054/miR‐508‐3p/PTEN [5, 8], our bioinformatic predictive model identified hsa_circ_0003563/EIF4A3/miR‐23‐5p and hsa_circ_0001161/miR‐665 as potential regulators of immune response and inflammation in periodontitis. This evidence concerns the gene EIF4A3 and periodontitis.