CSF3 and Sepsis: On the basis of these observations, the following clinical recommendations are suggested: (1) in men aged ≥65 years, baseline assessment of bone marrow reserve is crucial, and prophylactic G-CSF may be warranted to reduce neutropenic sepsis; and (2) in female patients, regular liver function monitoring (e.g., ALT, AST, bilirubin) is advised to identify drug-induced liver injury at an early stage.