A wide range of AIPs in IBD's animal models was analyzed in this systematic review, such as Vasoactive Intestinal Peptide, Thrombospondin peptide ABT‐898, Self‐assembling Peptide Hydrogel (SAPH, PuraMatrix), glucagon‐like peptide‐2 dimer (GLP‐22), Hydrostatin‐SN1 (H‐SN1), Cortistatin (A5), αs2‐casein, peptide 317, Peptide drove from annexin A1, annexin A1‐mimetic peptide Ac2‐26, Bubalus bubalis milk‐derived products (MBCP), AMP‐18 (Antrum Mucosal Protein). This evidence concerns the gene VIP and inflammatory bowel disease.