KLF4 tumor suppressor function in solid tumors (e.g., gastrointestinal, lung adenocarcinoma, prostate, pancreatic) and hematological malignancies (e.g., leukemia, lymphoma) has been associated with silencing of the KLF4 locus through different mechanisms (DNA methylation, micro RNAs, histone modifications) (reviewed in (36)). The gene discussed is KLF4; the disease is leukemia.