An analysis of TME characteristics in high-risk versus low-risk groups (Figure 6A), encompassing gene expression, immune cell infiltration, pathway activity, and metabolic features, demonstrated an enrichment of immune-suppressive cells (e.g., M0 macrophages) in the high-risk group, whereas anti-tumor immune cells (e.g., CD8+ T cells) were more prevalent in the low-risk group (Figure 6B). This evidence concerns the gene CD8A and neoplasm.