Analysis of immune infiltration using the MCP-counter algorithm demonstrated that CRC patients with the increased synthesis of S1P showed decreased infiltration of various immune cell types, such as CD8+ T cells, myeloid dendritic cells, cytotoxic lymphocytes, and neutrophils, when compared to patients with the reduced synthesis of S1P (Figure 3k). This evidence concerns the gene MBTPS1 and colorectal carcinoma.