TLR4 and hepatocellular carcinoma: The underlying mechanism of this progression primarily includes the activation of the TLR-4-mediated NF-κB signaling pathway, induction of the senescence-associated secretory phenotype (SASP) of hepatic stellate cells (HSCs), formation of NLRP3 inflammasome complex, secretion of various inflammatory factors in the liver, and progression of HCC (21).