To address the limitations of clinical trials and case reports in investigating PD-1/PD-L1-induced hyponatremia, our study is the first to leverage the FAERS database and apply multiple disproportionality analysis methods, including ROR, PRR, BCPNN, and MGPS, to quantify the association between PD-1/PD-L1 inhibitors and hyponatremia. The gene discussed is PDCD1; the disease is Hyponatremia.