CD274 and non-small cell lung carcinoma: In NSCLC, H3K18la not only promotes immune evasion by inhibiting the cytotoxicity of CTLs but also directly activates the transcription of pore membrane protein 121 (POM121), enhances the nuclear transport of MYC, and induces programmed cell death ligand 1 (PD-L1) expression, thereby exacerbating immune resistance (95).