H3K18la can also promote the transcription of absent in melanoma 2 (AIM2), thereby inhibiting the phosphorylation of STAT5B and promoting its proteasomal degradation, ultimately weakening the transcriptional promotion effect of STAT5B on Acyl-CoA synthetase long-chain family member 4 (ACSL4), thereby facilitating the progression of lung cancer (96). Here, AIM2 is linked to lung carcinoma.