She met the two major criteria (histological findings and lymph node enlargement), five laboratory minor criteria (high CRP titer, anemia, thrombocytosis, hypoalbuminemia, and hypergammaglobulinemia), and three clinical minor criteria (constitutional symptoms, liver enlargement, and leg edema), leading to a diagnosis of iMCD (plasma cell type) [2]. The gene discussed is CRP; the disease is anemia (phenotype).