CASQ2 and catecholaminergic polymorphic ventricular tachycardia: Inherited syndromes such as catecholaminergic PMVT (CPVT) are characterized by mutations primarily in the ryanodine receptor (RyR2) or calsequestrin-2 (CASQ2) genes, resulting in dysfunctional calcium handling under adrenergic stimulation and promoting delayed afterdepolarizations [16].