Resveratrol shows promise in preclinical studies for improving mood, reducing anxiety, and decreasing addiction-like behaviors, likely through mechanisms involving PDE4 inhibition, enhanced cAMP signaling, modulation of key neurotransmitters, and activation of neuroprotective- and neuroplasticity-related pathways like SIRT1 and BDNF. The gene discussed is PDE4A; the disease is Anxiety.