Meanwhile, restoring circadian homeostasis in CRC Targeting core clock genes (e.g., CRY, PER, BMAL1) via CRISPR-based epigenetic modifiers or small-molecule clock modulators (e.g., KL001 analogs) presents a promising approach to restoring circadian transcription in CRC (42, 43). The gene discussed is PER1; the disease is colorectal carcinoma.