Sato et al., (Helmbold et al., 2009) observed the frequent silencing of genes such as CDKN2A (encoding p16INK4a) and RASSF1A in MCV-positive MCC tumours, facilitating immune evasion and unchecked proliferation (Helmbold et al., 2009). The gene discussed is CDKN2A; the disease is neoplasm.