MYC and Burkitt lymphoma: The viral protein LMP1 activates AP-1, which recruits BRD4, a bromodomain protein that amplifies the transcription of oncogenic factors such as c-Myc and CCND1. In Burkitt lymphoma, EBNA2 works in conjunction with p300, a histone acetyltransferase, to acetylate chromatin at the c-Myc locus, enhancing cellular proliferation and contributing to oncogenesis (Kasprzyk et al., 2021).