TGFBR2 and Kaposi's sarcoma: This alteration silences tumor suppressor genes such as p16INK4a, TGF-β type II receptor (TbetaRII/TGFBR2), PDZ-LIM domain-containing protein 2 (PDLIM2), and CDH13, fostering unchecked cellular proliferation characteristic of Kaposi’s sarcoma (Shamay et al., 2006; Sun et al., 2015; Platt et al., 2002; Di Bartolo et al., 2008).