GZMA and neoplasm: As noted earlier, TILT-517 drives inflammation within the TME, underscoring a diverse range of cell death pathways: IFNg and granzymes A-B promote tumor cell apoptosis through cytotoxic T cells, Fas-FasL and perforin indicate active immune-mediated tumor cell killing via apoptosis, and granulysin levels reinforce this cytotoxic activity through membrane disruption.21