While mutations in v-raf murine sarcoma viral oncogene homologue B (BRAF), RAS, and neurofibromin 1 (NF1) are frequently observed in cutaneous malignant melanoma,11,12) little is known about the genetic profile of ARMM except that mutations in the KIT gene are found in approximately 30% of cases.13,14) To address this knowledge gap, we examined somatic mutations by analyzing and comparing primary tumor DNA with germline DNA. The gene discussed is NF1; the disease is cutaneous melanoma.