MAPK8IP3 and Abnormal brain morphology: For example, mutations in the BICD2 gene are associated with SMALED (Fiorillo et al., 2016; Oates et al., 2013; Peeters et al., 2013; Picher-Martel et al., 2020; Ravenscroft et al., 2016), while a study in C. Elegans showed that mutations in the neuronal expressed MAPK8IP3 gene (encoding the homologue of mammalian JIP3) results in disturbed LE/Lys trafficking associated to NEDBA (Neurodevelopmental Disorder with or Without Variable Brain Abnormalities) (Arimoto et al., 2011; Edwards et al., 2013).