MAPT and early-onset autosomal dominant Alzheimer disease: For example, Alzheimers disease is described to accumulate Tau-containing neurofilaments and Beta-amyloid plaques formed from APP (Amyloid Precursor Protein) (Grundke-Iqbal et al., 1986; Glenner and Wong, 1984; Delacourte and Defossez, 1986; Kosik et al., 1986; Wood et al., 1986; Nukina and Ihara, 1986; Kang et al., 1987).