Mutations in the human DYNC1H1 gene (encoding the 500 kDa dynein HC) have been associated to multiple neurological diseases (Marzo et al., 2019; Hoang et al., 2017; Becker et al., 2020) (an overview of the motor proteins with associated diseases and location of mutations can be found in (Figure 1)). Here, IMMT is linked to nervous system disorder.