So far, altered expression of EB1 has been observed in pediatric ependymoma (underexpression) (Suarez-Merino et al., 2005) and esophageal squamous cell carcinoma (overexpression) (Wang et al., 2005), as well as a lymphoblastic leukemia patient showing a fusion of EB1 and MLL (Mixed-Lineage Leukemia) (Fu et al., 2005). This evidence concerns the gene MAPRE1 and leukemia.