The most common syndromic forms of BDE are inactivating PTH/PTHrP signaling disorders (iPPSD), such as pseudohypoparathyroidism 1A (PHP1A, OMIM 103580), pseudopseudohypoparathyroidism (PPHP, OMIM 612463), acrodysostosis with multihormonal resistance (ACRDYS1, OMIM 101800), acrodysostosis without multihormonal resistance (ACRDYS2, OMIM 614613), and hypertension with brachydacytly syndrome (HTNB, OMIM 112410) (13–15). This evidence concerns the gene PTHLH and acrodysostosis.