The canonical β-catenin-dependent pathway of the Wnt signaling pathway is involved in myocardial fibrosis, where β-catenin forms a complex in the nucleus with transcription factors of T-cell factor/lymphoid enhancer factor (TCF/LEF) to stimulate the transcription of Wnt target genes, thereby leading to ECM deposition (39, 40). Here, HNF4A is linked to Myocardial fibrosis.