Ligand-Functionalized LNPs (120)Attaching targeting ligands (e.g., aptamers, peptides, antibodies) to LNPs enables specific delivery to tissues or cells.Example: ASGR1-targeting ligands for hepatocyte-specific delivery.Surface Engineering: (87)Incorporating molecules like transferrin or folate enhances receptor-mediated endocytosis.pH-Responsive Lipids:Designing lipids that respond to the acidic tumor or endosomal environments can boost targeted delivery. The gene discussed is ASGR1; the disease is neoplasm.