Notably, this is the first study to demonstrate that EA‐ST36 reverses HFD‐induced AD‐related pathology by promoting the autophagic degradation of inflammasome components (NLRP3 and ASC) and pro‐IL1B through the activation of TFEB and TFE3, mediated by MTORC1 inhibition (Figure 9). The gene discussed is NLRP3; the disease is Alzheimer disease.