This activation was confirmed by elevated phosphorylated NF‐κB‐p65 (RELA), NLRP3, pro‐/cleaved‐CASP1, and cleaved IL‐1β levels in the hippocampus of HFD‐fed 3xTg‐AD mice (Figure 3A,B). Here, CASP1 is linked to Alzheimer disease.