Given that SPLUNC1 is a gene modifier/biomarker for multiple lung diseases, and since protease-resistant peptides of SPLUNC1 can fully reverse neutrophilia, we propose that with excessive inflammation, a tipping point is reached, SPLUNC1 is degraded by neutrophil elastase, and Orai1 activity is increased, leading to even more inflammation. The gene discussed is ORAI1; the disease is lung disorder.