used a combination of an endothelialised microfluidic system and a murine passive immunisation model to show that NETs can form complexes with PF4 and HIT antibodies, which provide protection against nuclease digestion48 In instances of infection or inflammation, NETs have been shown to contribute to thrombosis via the release of chromatin, which can trap platelets, deactivate natural anticoagulants and bind clotting factors.60 The gene discussed is PF4; the disease is infection.