Here, we analyzed nine tumor markers (CA19‐9, AFP, PSA, CEA, CA125, CYFRA, CA15‐3, SCC antigen, and NCC‐ST439) in 119 patients with pancreatic cancer and 49 with hepatocellular carcinoma, alongside 590 healthy controls. The gene discussed is SERPINB3; the disease is hepatocellular carcinoma.