further extended this concept to tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), showing that a 5 nm spacing between TRAIL ligands optimized receptor clustering and apoptotic signaling in tumor cells (Figure 6b).[99] Beyond these examples, DNA origami has been employed to organize a wide range of receptor‐ligand interactions, including PD‐1 receptor ligands,[100] death receptor ligands (FasL, TRAIL, and CD95L),[101] insulin receptor ligands,[102] and Notch receptor ligands,[103] enabling detailed investigations into receptor‐mediated signaling and its biomedical applications. Here, TNFSF10 is linked to neoplasm.