Further research is required to examine associations of plasma biomarkers with different types of AD-type tau pathology (e.g., neurofibrillary tangles, neuropil threads, dystrophic neurites within the neuritic plaques and those surrounding ghost tangles [37, 38]) separately as well as with other types of tau lesions, such as argyrophilic grains, astrocytic plaques, tufted astrocytes, coiled bodies and aging-related tau astrogliopathy (ARTAG). The gene discussed is MAPT; the disease is Alzheimer disease.