8, Additional file 2: Table S1) revealed the appearance of CAR + CXCR6 + CD4 and CD8 blood T cells after passing the CRS maximum with a selective increase of CAR + CXCR6 + CD4 T cells in the CSF during ICANS (Additional file 1: Fig. S8B, C), highlighting the critical role of CXCR6 as a specific receptor that drives the preferential accumulation of cytotoxic CD4 CAR T cells in the CNS during ICANS onset. Here, CD4 is linked to congenital rubella syndrome.