MAPT and tauopathy: In addition, unilateral hippocampal injection of tau/α-syn co-polymers exacerbates the neuroanatomic transmission of seeded tau pathology compared to tau fibril alone, but does not trigger endogenous α-syn pathology. This suggests that co-polymers possess more potent transmission properties, preferentially in tauopathy models rather than in synucleinopathy [95].