As it pertains to inflammation in the CNS, EphB2 deletion in a murine stroke model was reported to decrease proinflammatory CCL2 and IL-6 in the ischemic zone, while EphB2 binding to astrocytic ephrin-Bs activated NF-kB signaling, suggesting a chronic inflammatory role for EphB2 [13]. Here, EPHB2 is linked to Stroke.