high mobility group AT-hook 1 (HMGA1) and high mobility group protein B2 (HMGB2) have the ability to advance several key pathways, like Wnt/β-catenin pathway, the phosphatidylinositol 3 kinase/protein kinase B (PI3 K/Akt) cascade, the Hippo signaling pathway, and the MAP kinase-ERK kinase/extracellular-signal-regulated kinase (MEK/ERK) pathway, all of which raise the malignancy of tumor cells [139–141]. The gene discussed is HMGA1; the disease is neoplasm.