In head and neck squamous cell carcinoma, NAT10 promotes lymph node metastasis and remodels the malignant niche surrounding head and neck squamous cell carcinoma cells via ac4C-dependent stabilization of the glycosylated lysosomal membrane protein (GLMP) transcript, which triggered the activation of the MAPK/ERK signaling pathway [99]. The gene discussed is NAT10; the disease is head and neck squamous cell carcinoma.