ESR1 and neoplasm: Utilizing 1368 latent factors from RNA-seq data, along with clinical features (i.e., ER/HER2/PR status, positive lymph nodes, age at diagnosis, and tumor size), LaGrACE identified six clusters (Fig. 4E–H; Table 1) significantly associated with molecular subtypes (P value < 2.2e-16, Chi-square test), disease-specific survival (P value = 1.31e-22), and distant (P value = 1.91e-21) and loco-regional relapse (P value = 1.45e-5), and clinical features (Appendix Table S1).