To unravel the physiological roles of PPM1K in renal fibrosis, we analyzed the RNA-sequencing dataset of a PPM1K-overexpressing HK2 cell line (GSE212681) and identified reduced expression of fibrosis-related genes such as Col1A1, Col2A1, CTGF, vimentin, and FN1 (Fig. EV3). Here, CCN2 is linked to renal fibrosis.