Among the genes predicted to be regulated by p300 in proximal tubule cells during renal fibrosis, we selected the POSTN, FSTL1, and FSCN1 genes, as these encode secreted proteins that mediate interactions with surrounding cells and affect the mesenchymal transition (Cho et al, 2023; Dorafshan et al, 2022; Jia et al, 2021; Jin et al, 2020; Li et al, 2018; Liu et al, 2017; Louis et al, 2019; Pontemezzo et al, 2021; Sisto et al, 2022; Wu et al, 2024; Xu-Dubois et al, 2020; Xu-Dubois et al, 2016; Zhang et al, 2018). This evidence concerns the gene POSTN and renal fibrosis.