EP300 and Hepatic fibrosis: In liver fibrosis, p300 produced by hepatic endothelial cells regulates fibrosis by mediating C-C motif chemokine ligand 2 while in hepatic stellate cells, p300 protein stability is increased by mechanical stress, which promotes their transition into myofibroblasts (Dou et al, 2018; Gao et al, 2021b).