Based on our demonstration that p300 promotes the secretion of POSTN, FSTL1, and FSCN1 in renal proximal tubule cells, thereby increasing the EndMT, we next investigated whether selective inhibition of p300 suppressed the secretion of these three proteins in a UUO-induced renal fibrosis mouse model. This evidence concerns the gene FSTL1 and renal fibrosis.