In addition, endothelial-specific p300 has been reported to play an important role in mediating liver fibrosis, and our results also showed a slight increase in endothelial p300 levels, though less than in proximal tubule cells, suggesting that additional studies are needed to elucidate the physiological role and molecular mechanisms of endothelial p300 in renal fibrosis (Gao et al, 2021b). The gene discussed is EP300; the disease is Hepatic fibrosis.