In addition, by analyzing a public GEO dataset of CKD patients, we found that the expression of these three genes was increased in CKD patients and in PTCs from CKD patients, suggesting that increased p300 upon induction of renal fibrosis activates transcription of POSTN, FSTL1, and FSCN1 genes (Appendix Fig. S19A,B). Here, EP300 is linked to renal fibrosis.