Notably, in accordance with human data, silencing of the orthologous murine gene Olfr78 (Or51e2) similarly increased levels of MHCII and decreased expression of CD206 and ARG1 in murine BMDMs exposed to conditioned media from Pten−/−Trp53−/− tumor cells (Extended Data Fig. 8d). The gene discussed is MRC1; the disease is neoplasm.