CD8A and cancer: In accordance with the systemic infusion model, we observed reshaping of the tumor microenvironment, with an increase in CD206−MHCII+ macrophages and a decrease in CD206+MHCII− macrophages (Fig. 4h), an increase in CD8+CD39+ cancer-specific T lymphocytes and a decrease in the frequency of Treg cells (Fig. 4i).