CD206 expression in GFP+ macrophages was reduced across all treatment groups compared to untreated LGP-control macrophages (Fig. 5i), and we observed increased abundance of CD8+CD39+ cancer-specific T lymphocytes and decreased frequency of Treg cells across all treatment groups compared to the untreated LGP control (Fig. 5j). The gene discussed is ENTPD1; the disease is cancer.