Although most transcriptional regulators are present in the nucleus at levels below the LC-MS/MS detection limit, unbiased proteomics documented reductions in YAP and JUN (Fig. 3A; Dataset EV7), nuclear proteins linked to prostate cancer progression and recurrence (Nguyen et al, 2015; Ouyang et al, 2008; Riedel et al, 2021; Lee et al, 2021; Thakur et al, 2014; Edwards et al, 2004; Kuser-Abali et al, 2015). This evidence concerns the gene JUN and Familial prostate cancer.