KPNB1 and prostate cancer: Consistent with either of these non-mutually exclusive hypotheses, 893-PAL did not isolate importin-α proteins or nuclear pore proteins (Dataset EV2), and treatment with SH-BC-893 dramatically reduced the amount of KPNB1 present at the nuclear rim and in the nucleus of 22Rv1 prostate cancer cells (Fig. 2D).