The prostate cancer drivers MYC and the androgen receptor (AR) are degraded in response to PP2A-dependent dephosphorylation, but also rely on KPNB1 to reach their target genes in the nucleus (Antonarakis et al, 2014; Kuser-Abali et al, 2015; Labbé and Brown, 2018; Rodriguez-Bravo et al, 2018; McClinch et al, 2018; Sandhu et al, 2021; Ruvolo, 2016) (Appendix Fig. S7B). Here, KPNB1 is linked to Familial prostate cancer.