Consistent with either of these non-mutually exclusive hypotheses, 893-PAL did not isolate importin-α proteins or nuclear pore proteins (Dataset EV2), and treatment with SH-BC-893 dramatically reduced the amount of KPNB1 present at the nuclear rim and in the nucleus of 22Rv1 prostate cancer cells (Fig. 2D). Here, KPNB1 is linked to Familial prostate cancer.