KLF4 and neoplasm: ChIP assays revealed that SMYD3 was recruited with c-MYC to Wnt responsive elements (WREs) of several c-MYC targets, including CD44, SOX9, KLF4, NANOG, OCT4, SOX2, and CCND1, which are all involved in CRC stemness features and tumor progression37 (Fig. 3d).