MYC and colorectal carcinoma: One of the main players involved in CRC-SC biology is c-MYC, which acts as a link between stemness and malignancy.69 c-MYC has been found overexpressed in up to 80% of sporadic CRCs70 and consistently upregulated in CRC-SCs, while its downregulation has been shown to prevent CRC-SC self-renewal and xenograft growth.69 Moreover, deletion of the c-MYC gene has been shown to suppress intestinal tumorigenesis in CRC mouse models, indicating that its function is essential in this process.71