SMYD3 and neoplasm: After 16 days, tumor volume was significantly lower in mice xenografted with SMYD3-KO HCT-116 cells compared to WT HCT-116 cells (Fig. 6b), consistent with previous reports indicating that the absence of SMYD3 impairs tumor development.57,58 At the conclusion of the study, xenograft tumors were explanted and subjected to histological evaluation (Fig. 6c).