SMYD3 and colorectal carcinoma: Ki67 is widely recognized as a cell proliferation marker; moreover, it plays a role in the maintenance of the stem cell niche and hence can also be used as a CSC marker.55 Based on our results, SMYD3 pharmacological inhibition reduced Ki67 staining in patient-derived CRC-SCs (Fig. 5e), and this effect was associated with the induction of apoptosis (Fig. 5f).