ChIP assays revealed that SMYD3 was recruited with c-MYC to Wnt responsive elements (WREs) of several c-MYC targets, including CD44, SOX9, KLF4, NANOG, OCT4, SOX2, and CCND1, which are all involved in CRC stemness features and tumor progression37 (Fig. 3d). Here, SMYD3 is linked to colorectal carcinoma.