MYC and colorectal carcinoma: We found that among the 57 c-MYC target genes showing decreased expression after EM127 treatment, 12 (21%) are known to be oncogenes, whereas among the 111 c-MYC target genes showing increased expression after EM127 treatment, only 1 (1.11%) is known to be a tumor suppressor in CRC (Fig. 4e).