This analysis showed marked tumor regression in EM127-treated HCT-116-xenografted mice, which was associated with a marked reduction in the average Ki67 positivity score (40% vs 80% in vehicle-treated animals) (Fig. 6g) and increased levels of Cleaved PARP and Cleaved Caspase 3 (Fig. 6h). The gene discussed is MKI67; the disease is neoplasm.