STYK1 and pancreatic neoplasm: Targeting v-ATPase using its inhibitors, such as bafilomycin and concanamycin, showed marked inhibition of Wnt/β-catenin signaling in colorectal cancer and proposed the blockade of v-ATPase as a viable option for colorectal cancer treatment.61 We previously also revealed that FAM83A-targeting peptides destabilize β-catenin and suppress the malignant properties of pancreatic cancer cells.25 Consistently, here we further defined the inhibitory role of STYK1-derived peptides in pancreatic cancer development.