Multivariate regression of IHC data from pancreatic cancer tissue microarrays demonstrated STYK1 overexpression exhibits significant covariance with TNM stage, tumor size and perineural invasion, a pathognomonic feature of locally advanced or metastatic PDAC, serves as an independent prognostic indicator correlating with aggressive disease progression and reduced survival outcomes (Supplementary Fig. 1f).20 Moreover, survival modeling via log-rank test confirmed elevated STYK1 expression portends diminished median overall survival (OS) (Fig. 1e). This evidence concerns the gene STYK1 and familial pancreatic carcinoma.