STYK1 and cancer: Serine/threonine/tyrosine kinase 1 (STYK1), a proto-oncogenic transmembrane receptor alternatively termed NOK, which consists of a kinase domain, intracellular domain (ICD), and transmembrane domain, was identified as an oncogene with high transformation potential in multiple cancer types.14–17 Recently, our group recognized that STYK1 depletion disrupts autophagosome biogenesis, establishing it as a critical modulator of autophagic flux.