Expectedly, the endogenous interaction between GSK3β, β-catenin, and STYK1 was confirmed using immunoprecipitation and immunofluorescence assays with specific antibodies in AsPC-1, PANC-1, SW1990, and MIA-PACA-2 cells and pancreatic cancer patient's tissues (Fig. 3b–d, Supplementary Fig. 3a, b). Here, STYK1 is linked to pancreatic neoplasm.