STYK1 and familial pancreatic carcinoma: In the present study, we reported that higher STYK1 expression correlates with poor pancreatic cancer survival and STYK1 deletion alleviates pancreatic cancer progression using LSL-KrasG12D/+; Trp53R172H/+; Pdx1Cre; Styk1−/− mice (KPCS mice).