Hypoxia-PH inhibits AMPK causing NF-κB/NLRP3-mediated PASMC inflammation, pyroptosis, and proliferation, ultimately causing pulmonary vascular remodeling.382 Activation of AMPK prevents MCT-PAH in rats by suppression of NF-κB-mediated autophagy activation.383 Upregulation of α-enolase levels during hypoxia-PH promotes PASMC proliferation via AMPK-Akt activation.253. The gene discussed is AKT1; the disease is pulmonary arterial hypertension.