SOD2 and pulmonary arterial hypertension: In turn, SOD2-deficient CD11b+ myeloid cells were found to enhance apoptosis resistance and promote the over-proliferation of human PASMCs by upregulating NLRP3.221 Additionally, STING has been shown to affect the expression of the NLRP3 inflammasome, promoting the proliferation of PASMCs during Su/Hx-PAH.8