FGF2 and its receptor, FGFR, play a dual role in the pathogenesis of PH, contributing to adaptive responses in certain contexts while driving pathological progression in conditions like PAH.212,282–284 FGF2 is a potent mitogen that influences various cellular processes, including proliferation, migration, and survival, especially in PASMCs and PAECs.282–284. The gene discussed is FGF2; the disease is pulmonary arterial hypertension.