BMPR2 and pulmonary arterial hypertension: In mouse PMVECs, Bmpr2 defects increase 3-(2-deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-one, causing mitochondrial damage as one of ROS-mediated mitochondrial DNA adducts.53 Mitochondria-mediated apoptosis and altered kinetics are also implicated in PAH development.