Inhibition of PDGF or CaSR effectively reduces progression in IPAH models, suggesting that the CaSR-PDGF signaling axis plays a pivotal role in disease pathogenesis.385 The complex interplay between CaSR and various signaling pathways underscores the importance of CaSR in PH pathogenesis and presents numerous opportunities for therapeutic intervention. The gene discussed is CASR; the disease is idiopathic pulmonary arterial hypertension.