BMPR2 and pulmonary arterial hypertension: For instance, Reynolds and colleagues developed adenovirus vectors containing the BMPR2 gene, which targeted pulmonary vascular endothelium and ameliorated pulmonary hemodynamics and RVH in hypoxia-PH, and MCT-PAH rats.386,387 These findings suggest the great potential of gene therapy, regardless of whether PH is associated with suppression of BMPR2 levels or a mutation.