KIF23 increases pyroptosis and proliferation in PASMCs of IPAH, hypoxia-PH, and MCT-PAH models, by increasing the expression of Caspase-3, NLRP3, and HMGB1 through the activation of PI3K/Akt and MAPK pathways. This evidence concerns the gene HMGB1 and pulmonary arterial hypertension.