In 2022, Shimauchi et al. demonstrated PARP1/PKM2 signaling in PH, with the pathway gaining recognition as a critical player in the development of PH.343 Specifically, their study identified the PARP1/PKM2 axis as a key driver of maladaptive RV remodeling in PAH. The gene discussed is PKM; the disease is pulmonary arterial hypertension.