This results in impaired migration and attachment to the inner duct.280 Additionally, decreased expression of Wnt5a in PAH PMVECs inhibits Wnt/PCP in co-cultured pericytes, causing diminished migration and polarization of pericytes toward the tubular structures formed by PMVECs, which in turn reduces the activity of newly formed blood vessels.281. The gene discussed is WNT5A; the disease is pulmonary arterial hypertension.