The concerted action of STING and NLRP3 in macrophages contributed to an intensified inflammatory response and enhanced vascular proliferation in rats with Su/Hx-PAH.8 Furthermore, several studies have demonstrated that directing interventions towards the NLRP3 signaling pathway holds promise in alleviating inflammation, leading to the attenuation of PH.223–225. The gene discussed is NLRP3; the disease is pulmonary arterial hypertension.