WNT7A and pulmonary arterial hypertension: Kocak et al. found that the expression of Wnt1 and Wnt2 genes was significantly increased in patients with scleroderma-PAH.269 However, the expression of Wnt7a also varies in different PH models.267,270 In the classic Wnt/β-catenin pathway, activation leads to β-catenin translocating to the nucleus, where it binds transcription factors to enhance the expression of target genes.