NLRP3 and pulmonary arterial hypertension: Ellagic acid exhibits preventive effects against MCT-PAH by specifically targeting and inhibiting NLRP3 inflammasome activation.439 Moreover, the protective effect of Sulforaphane on PAH via the prevention of RV injury and pulmonary vascular remodeling was associated with the reduction of the NLRP3 expression.224 Pharmacological interventions also play a crucial role in NLRP3 signaling modulation for PAH therapy.