CASR and idiopathic pulmonary arterial hypertension: Inhibition of Notch3 or treatment with DAPT (a selective inhibitor of γ-secretase) in experimental models of hypoxia-PH attenuates these effects, highlighting the contribution of Notch-CaSR signaling to PH development.384 Moreover, the involvement of CaSR in vascular remodeling is further supported by its interaction with PDGF signaling, where PDGF upregulates CaSR expression in PASMCs, driving excessive proliferation and vascular remodeling in IPAH.