TNC and pulmonary arterial hypertension: In samples from PAH patients and allergen-induced asthma mouse models, the upregulation of Wnt7b enhances the expression of the ECM protein tenascin C through β-catenin activation.275 The elevated levels of fatty acid-binding protein 5 in PAFs of mice with left ventricular secondary PH activate the Wnt/β-catenin pathway.