WNK1 and pulmonary arterial hypertension: Inhibiting WNK1 in an MCT-PAH rat model has been demonstrated to activate AMPK, correcting metabolic dysregulation, and preserving mitochondrial enzyme levels, thereby improving both systolic and diastolic function in the right ventricle.261 Moreover, intermittent fasting has been shown to preserve RV function in PAH by activating AMPK to improve lipid metabolism and normalize mitochondrial and microtubule dynamics.262