A recent study shows that SMYD2 expression is elevated in PASMCs during PH, promoting proliferation and pulmonary vascular remodeling by inhibiting PPARγ activity through monomethylation, which enhances mitophagy.307 Additionally, reduced BMPR2 expression in PAH impairs PAEC function, disrupting PPARγ/β-catenin-mediated APLN production, which promotes PAEC survival.308 BMP-2 signaling through BMPR2 prevents PASMC proliferation by activating PPARγ and promoting apoE production, which protects against PAH. The gene discussed is APLN; the disease is pulmonary arterial hypertension.