ANGPT1 and colitis: Previous studies have demonstrated its crucial role in modulating inflammatory responses under various pathological conditions, including colitis, pulmonary fibrosis, hepatic steatosis, and ischemic stroke.[8] Moreover, Ang (1‐7) can promote the M2 polarization of microglia/macrophages.[9] We hypothesize that Ang (1‐7) administration may improve the IVD microenvironment by modulating macrophage polarization.