AKT1 and cancer: Autophagy is a conserved cellular metabolic pathway that maintains intracellular stability, plays a crucial regulatory role in inflammation, and affects the pathological progression of inflammatory diseases.[23] The PI3K/AKT/mTOR pathway is widely recognized as a fundamental intracellular signaling pathway involved in normal cell physiology and cancer pathology that inhibits autophagy when activated.[24] We previously demonstrated that A_Man and MSN@A_Man effectively inhibit the PI3K/AKT/mTOR pathway.