ELN and intervertebral disk degenerative disorder: The extracellular matrix (ECM) is a complex 3D network structure that comprises gel‐like molecules including collagen, elastin, integrin, and proteoglycans,[37] which constitute the microenvironment and are closely linked to cell survival, regeneration, repair, and immune response.[38] The gradual depletion of notochordal‐like and chondrocyte‐like nucleus pulposus (NPCs) leads to an imbalance in ECM metabolism during IDD.