We next tested the biochemical response to either SHP2 inhibition or SOS1 inhibition across a broader range of NF1 mutant pNF (NF9511b) or MPNST (JH002-2, JW18.2) cell lines (SI Appendix, Fig. S8), revealing SHP2 inhibition showed a consistently superior biochemical response and underscoring the likely importance of SOS2 compensation in NF1 mutant PNS tumor cells (Fig. 3E). This evidence concerns the gene PTPN11 and neoplasm.