MAP2K3 depletion can reduce cancer cell proliferation and viability.[38] Xu G study proved that MAP2K3 was significantly inhibited in human HCC tumor tissues.[36] By up-regulating its mRNA and protein level expression, it can promote hepatocellular carcinoma HepG2 cell proliferation.[14] This study showed that MAP2K3 was under-expressed in LIHC tissues, and the protein expression was the opposite. This evidence concerns the gene MAP2K3 and cancer.