Elevated MAP2K5 was related to OS, PFS, and DSS of male patients, RFS and PFS of Grade2, Stage1 and AJCC_T1, OS of Grade3 and microvascular invasion, OS, RFS, PFS, and DSS of Stage3 + 4 and AJCC_T3 in male patients.Our study shows that high expression of MAP2K5 can predict the occurrence and severity grade of liver cancer, but high expression also reflects better prognosis of patients. The gene discussed is MAP2K5; the disease is liver cancer.