SERPINB3 and neoplasm: To mitigate the negative impacts of misdiagnosis and missed diagnoses, multidisciplinary collaboration can be enhanced by integrating imaging examinations, histopathology, and other tumor markers to comprehensively assess the patient’s condition.[1] Additionally, through education and training, the ability of medical personnel to interpret SCC-Ag test results can be improved, thereby avoiding misdiagnosis or missed diagnoses due to the limitations of SCC-Ag reference ranges.