High LH levels also lead to premature luteinisation of follicular granulosa cells and premature maturation of oocytes by inhibiting the action of inhibin, which influences the development and maturation of oocytes and embryo quality.[41,51,52] The quality of oocytes in patients with PCOS was found to be decreased, mostly because of endocrine abnormalities in PCOS.[20] In the present study, a retrospective analysis was conducted of the clinical data of infertile patients with PCOS who underwent COS using an antagonist protocol. This evidence concerns the gene PLOD1 and Infertility.