CXCL12 and gastric cancer: In addition, in a separate study, we used CRISPR/Cas9 technology to construct an inducible expression gene editing vector targeting CXCR4 and demonstrated its gene editing efficiency and ability to regulate cell chemotaxis in the human gastric cancer cell line MKN-45,[15] which suggests that it is feasible to regulate the movement of neutrophils by modulating SDF-1/CXCR4 signals using a gene editing technique.